Inferring gene ontologies from pairwise similarity data

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چکیده

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Inferring gene ontologies from pairwise similarity data

MOTIVATION While the manually curated Gene Ontology (GO) is widely used, inferring a GO directly from -omics data is a compelling new problem. Recognizing that ontologies are a directed acyclic graph (DAG) of terms and hierarchical relations, algorithms are needed that: analyze a full matrix of gene-gene pairwise similarities from -omics data; infer true hierarchical structure in these data rat...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2014

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btu282